Plasma Oxalate in Patient With Short Bowel

N/ACompletedNCT04119765

Hospices Civils de Lyon47 enrolled

Overview

Hyperoxaluria due to fat malabsorption is seen in patients suffering from short bowel and can lead to stones and nephrocalcinosis. Not all patients are prone to these renal complications. only urinary oxaluria is measured in practice. Plasma oxalate shouldn't increase theoretically in these patients. However recent report showed an increase of plasma oxalate in patient with enteric hyperoxaluria. The aim of this study is to assess the plasma oxalate distribution in this specific population to have a new tool to predict renal complication of these patients.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Short Bowel Syndrome Hyperoxaluria Hyperoxalemia

Interventions

Blood samplingBIOLOGICAL

blood sampling will be used to perform oxalemia and FGF23 quantitative analysis

Urine samplingBIOLOGICAL

urine sampling will be used to measure glycolate urinary rate (glycolaturia) and to perform urinary inflammation markers quantitative analysis

Pulse Wave Velocity (PWV) measurementPROCEDURE

PWV will be measured thank to the Complior® device

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age ≥ 18 years * Type II short bowel for more than 6 months * Affiliated to a social health care Exclusion Criteria: * Primary hyperoxaluria * Other type of short bowel than type II * Minor patient or major patient protected by the law

Locations (1)

Nephrology Department, Edouard Herriot Hospital

Lyon, France

Outcomes

Primary Outcomes

Plasma oxalate rate (oxalemia)

this sample measures the plasma oxalate rate

Time frame: at inclusion

Data from ClinicalTrials.gov

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