To evaluate the effect of oxycodone and sufentanil in preventing cardiovascular responses to tracheal intubation in the patients with coronary heart disease (CHD).
Laryngoscopy and tracheal intubation can provoke an increase of blood pressure (BP) and/or HR \[1.2\]. This hemodynamic stress may lead to an imbalance between myocardial oxygen consumption and supply and therefore induce myocardial ischemia, which may be endurable in the patients with normal cardiovascular condition but is potential harmful to the patients with coronary heart disease. Thus it is critical to attenuate the cardiovascular stress induced by laryngoscopy and endotracheal intubation in the high risk patients.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
OTHER
Masking
QUADRUPLE
Enrollment
50
induction with 0.3mg/kg of oxycodone in general anesthesia
induction with 0.3 µg/kg of Sufentanil in general anesthesia
shengjing hospital of China medical university
Shenyang, Liaoning, China
blood pressure(SBP)、diastolic blood pressure(DBP)、mean arterial pressure(MAP)
Under local anesthesia invasive artery line was put to the patients to monitor systolic blood pressure(SBP)、diastolic blood pressure(DBP)、mean arterial pressure(MAP)
Time frame: one second before anesthesia induction, the moment when tracheal catheter passes through glottis and at 1, 3, 5 min after tracheal intubation
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