The Association Between Blood Eosinophilsp in Thai COPD Patients: A Prospective Study

Prince of Songkla University145 enrolled

Overview

The association of blood eosinophil as a biomarker for eosinophilic Thai COPD patients, such as COPD exacerbation, hospital admission, lung functions and mortlity.

The prospective one year study in Thai COPD patients for the clinical outcomes of COPD compare between eosinophilic and non-eosinophilic which determine by blood eosinophil counts equal or more than 300 cells/microliters. The primary outcomes was COPD exacerbation, the secondary outcomes were lung function, dyspnea and quality of life.

Study Type

OBSERVATIONAL

Enrollment

145

Conditions

Copd

Interventions

observatoryOTHER

observation for 1 year period

Eligibility

Sex: ALLMin age: 40 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * diagnosis of COPD by GOLD criteria Exclusion Criteria: 1. high blood eosinophil from known causes such as systemic corticosteroid use, malignancy, parasitic infection 2. Patients who had previous acute exacerbation within 30-day before study entry 3. Patients who had previous systemic corticosteroids used within 30-day before study entry

Locations (1)

Faculty of Medicine, Prince of Songkla university

Songkhla, Thailand

Outcomes

Primary Outcomes

Acute worsening of respiratory symptoms

acute severe worsening of respiratory symptoms

Time frame: 1 year

Secondary Outcomes

Physiological outcomes

Forced expiratory volume in one second

Time frame: 1 year

health related quality of life

Chronic Obstructive Pulmonary Disease Assessment Test (CAT) scores which the minimum 0 and maximum 40 values, and whether higher scores mean a worse outcome.

Time frame: 1 year

Data from ClinicalTrials.gov

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