Women of reproductive age had their vitamin A stores estimated by retinol isotope dilution and then were given vitamin A supplements near the US vitamin A RDA or placebo for 42(USA) or 60 (Indonesia) days, after which retinol isotope dilution was repeated and the change in vitamin A stores was determined in each group to estimate how much vitamin A is needed to maintain nutrient balance in these women.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
TRIPLE
Enrollment
70
University of Wisconsin - Madison
Madison, Wisconsin, United States
Pusat Teknologi Terapan Kesehatan dan Epidemiologi Klinik
Bogor, Indonesia
Total body vitamin A stores (micromoles of vitamin A)
Change in total body stores of vitamin A before and after intervention, measured by retinol isotope dilution
Time frame: Baseline and after 42 to 60 days
Total vitamin A liver reserves (micromoles vitamin A per gram liver)
Change in total liver reserves of vitamin A before and after intervention, measured by retinol isotope dilution
Time frame: Baseline and after 42 to 60 days
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