The aim of the study is to compare the impact of two different insulin dose calculation on postprandial glycemia after mixed meal in children with type 1 diabetes mellitus.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
76
A kind of bolus insulin will be insulin glulisine if participant used insulin glulisine before entering the trial.
A kind of bolus insulin will be insulin aspart if participant used insulin aspart before entering the trial.
A kind of bolus insulin will be insulin lispro if participant used insulin lispro before entering the trial.
Warsaw Medical University
Warsaw, Poland
Postprandial glycemia
Postprandial blood glucose excursion measured by self monitoring of blood glucose (SMBG).
Time frame: 30 minutes after meal
Postprandial glycemia
Postprandial blood glucose excursion measured by self monitoring of blood glucose (SMBG).
Time frame: 60 minutes after meal
Postprandial glycemia
Postprandial blood glucose excursion measured by self monitoring of blood glucose (SMBG).
Time frame: 90 minutes after meal
Postprandial glycemia
Postprandial blood glucose excursion measured by self monitoring of blood glucose (SMBG).
Time frame: 120 minutes after meal
Postprandial glycemia
Postprandial blood glucose excursion measured by self monitoring of blood glucose (SMBG).
Time frame: 150 minutes after meal
Postprandial glycemia
Postprandial blood glucose excursion measured by self monitoring of blood glucose (SMBG).
Time frame: 180 minutes after meal
Postprandial glycemia
Postprandial blood glucose excursion measured by self monitoring of blood glucose (SMBG).
Time frame: 210 minutes after meal
Postprandial glycemia
Postprandial blood glucose excursion measured by self monitoring of blood glucose (SMBG).
Time frame: 240 minutes after meal
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Postprandial glycemia
Postprandial blood glucose excursion measured by self monitoring of blood glucose (SMBG).
Time frame: 270 minutes after meal
Postprandial glycemia
Postprandial blood glucose excursion measured by self monitoring of blood glucose (SMBG).
Time frame: 300 minutes after meal
Glucose Area Under the Curve (AUC)
Measurements based on Continuous Glucose Monitoring System (CGMS)
Time frame: 5 hours study period
The Difference Between The Maximum and Baseline Glucose Level - mean amplitude of glycaemic excursion (MAGE)
Measurements based on SMBG
Time frame: 5 hours study period
Hypoglycemia Episodes
Hypoglycemia defined as a plasma glucose concentration below 70mg/dl with or without symptoms
Time frame: 5 hours study period
Time in target postprandial glycemia
Time spent in the target range between 70 and 180 mg/dL based on CGMS
Time frame: 5 hours study period