VDR and TFIP11 Gene Polymorphism and Gene-environmental Interaction in Adults

Recep Tayyip Erdogan University Training and Research Hospital160 enrolled

Overview

VDR and TFIP11 Gene polymorphism and gene-environment interactions on caries etiology and susceptibility in adults.

To date, genes can be grouped into categories based on the factor influencing dental caries. The major candidate gene categories to date include enamel formation genes, immune response genes, genes related to saliva, and genes related to taste and dietary habits. TFIP11 and VDR genes are related to enamel formation genes

Study Type

OBSERVATIONAL

Enrollment

160

Conditions

Low Caries Experience High Caries Experience

Interventions

high caries experienceGENETIC

DNAs were obtained from epithelial cells in buccal mucosa and were extracted with Genomic DNA Isolation Kit

Eligibility

Sex: ALLMin age: 24 YearsMax age: 40 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * adult be between 24 and 40 years old * subject has DMFT (Decayed, Missing, Filled, Permanent Tooth) DMFT≤4 , or, DMFT\>13.9 Exclusion Criteria: * systemic or genetic disorders * orthodontic appliances * pregnant women

Locations (1)

Recep Tayyip Erdogan University Dentistry Faculty

Rize, Turkey (Türkiye)

Outcomes

Primary Outcomes

past caries experience

Each tooth will be examined and recorded as decayed, missing, or filled

Time frame: 3 weeks

Secondary Outcomes

Plaque index

The plaque amount is scored by using Silness\&Löe Plaque Index plaque index PI\<1.0 healthy PI 1.1-2.0 mild PI\>2 high plaque

Time frame: 3 weeks

Data from ClinicalTrials.gov

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