Truth or Dare; Artificial Blastocoel Collapse Using Laser Before Blastocyst's Vitrification Versus Non-laser Usage

Benha University10 enrolled

Overview

: This prospective randomized observational study aimed to compare behavior of artificially collapsed blastocysts to blastocysts that were vitrified without artificial collapse.

One arm study of 60 patients with sibling blastocysts divided into 2 groups: Study group (artificially laser-collapsed blastocysts; n=71) \& control group (blastocysts were vitrified without laser collapse; n=66) then reexpansion speed and survival rate was assessed immediately \& at 140 min after thawing and compared between two groups.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

TRIPLE

Enrollment

Conditions

Blastocyst Disintegration

Interventions

laser assisted collapseDEVICE

Apply 1-2 pulses of laser using the Saturn between 2 adjacent trophectoderm cells away from the inner cell mass in the blastocysts

Eligibility

Sex: FEMALEMin age: 20 YearsMax age: 37 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age limit 20-37 At least 6 good quality blastocysts per case. expansion rate 3-4 Exclusion Criteria: * bad quality blastocysts expansion rate less than 3

Locations (1)

Hawaa Fertility Center

Banhā, Qalyubia Governorate, Egypt

Outcomes

Primary Outcomes

survival rate

survival rate will be assessed immediately after thawing and compared between both groups.

Time frame: immediately after thawing

survival rate

survival rate will be assessed at 140 minutes after thawing and compared between both groups.

Time frame: 140 min after thawing

Data from ClinicalTrials.gov

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