The investigators seek to advance the understanding of obstructive sleep apnea as it relates to different ethnic origins as well as sex differences. The investigators will compare Somali patients with known obstructive sleep apnea (OSA) to individuals without OSA, and to individuals of other ethnic/racial origins to determine the risk factors (genetic and/or physiologic) associated with developing cardiovascular diseases. This will help the investigators to understand the unique sleep pathology of individuals of African descent.
Participants can be healthy volunteers or volunteers diagnosed with obstructive sleep apnea. All patients may undergo a sleep study (i.e. hospital or home-based), physical examination, questionnaires, blood and urine samples, ultrasound scan of the heart and brachial artery in the arm, CT scan, DEXA scan, paced breathing test, cardiopulmonary test and chemo-sensitivity test.
Study Type
OBSERVATIONAL
Enrollment
600
Mayo Clinic
Rochester, Minnesota, United States
RECRUITINGTo assess the prevalence of obstructive sleep apnea
Measure the apnea-hypopnea index (AHI) to determine burden of obstructive sleep apnea. Based on the AHI, sleep apnea will be diagnosed if the AHI is ≥5 events/hour.
Time frame: 10 years
To determine the severity of obstructive sleep apnea
The severity of OSA is classified based on the AHI as follows: None/Minimal: AHI \< 5 per hour, Mild: AHI ≥ 5, but \< 15 per hour, Moderate: AHI ≥ 15, but \< 30 per hour, Severe: AHI ≥ 30 per hour.
Time frame: 10 years
24 hour mean arterial pressure
Ambulatory measure of blood pressure in mmHg
Time frame: 10 years
Vascular endothelial function
Change in brachial artery diameter in response to hyperemia
Time frame: 10 years
Insulin sensitivity
Oral glucose tolerance testing
Time frame: 10 years
Body composition
Percentage body fat content
Time frame: 10 years
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