Randomized, placebo-controlled, double-blind, placebo-controlled clinical trial consisting of 15 triathletes in which it is intended to observe less inflammatory damage at the muscular level after performing eccentric exercises.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
QUADRUPLE
Enrollment
15
Composition of the Experimental Product: Concentrated oil of Tridocosahexaenoin-AOX® \* (350 mg per capsule), α-tocopherol and coating agent (gelatin). Each capsule is 700 mg, of which 500 mg is oil. Placebo composition: Olive oil (each capsule is 700 mg). Number of capsules: 6 per day, for any of the two products. The dose taken daily is 2.1 g / day for DHA. Supplementation Period: Each group completed two 10-week consumption periods for each of the products, with an intermediate washing period of 4 weeks (28 days).
Catholic University of Murcia
Murcia, Spain
Inflammatory markers
Changes in the inflammatory marker: C-reactive protein (ml / dl). It is measured in venous blood by blood extraction.
Time frame: It was measured before and after consumption of the supplement. In each of the times it was measured four times. Before performing the eccentric exercises, just after, at 24 and 48 hours later.
muscle damage
Changes in markers of muscle damage will be measured by serum lactate dehydrogenase (IU / L)
Time frame: It was measured before and after consumption of the supplement. In each of the times it was measured four times. Before performing the eccentric exercises, just after, at 24 and 48 hours later.
connective tissue injury
changes in markers of connective tissue injury: serum collagenase. They will be measured by blood extraction.
Time frame: It was measured before and after consumption of the supplement. In each of the times it was measured four times. Before performing the eccentric exercises, just after, at 24 and 48 hours later.
Hematological variables: LEUCOCITS AND PLATES
changes in the hematological profile. The samples are analyzed by the laboratory analyzer: BA 400 BioSystems
Time frame: It was measured before and after supplement consumption. In each of the times it was measured four times. 1: before performing the eccentric exercises, 2: just after, 3: at 24 hours after and 4: 48 hours later.
Biochemical variables
changes in lipid profile: : basal glycemia(mg/dl), lipid profile: total cholesterol (mg / dl), high density lipoprotein (mg / dl), low density lipoprotein (mg / dl), triglycerides (mg / dl), atherogenic index.
Time frame: It was measured before and after consumption of the supplement. In each of the times it was measured four times. Before performing the eccentric exercises, just after, at 24 and 48 hours later.
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Variable for the evaluation of fatigue: Subjective perception test of Borg's effort
change in the perception of fatigue
Time frame: at the end of the stress test with the multipower. It was measured three times. 1: at the end of the test, 2: at 24 hours, 3: at 48 hours.
Perception of pain through the analog visual scale.
changes in the perception of muscle pain. Muscle pain will be measured from 0 (no pain), to 10 (unbearable pain).
Time frame: at the end of the stress test with the multipower. It was measured three times. 1: at the end of the test, 2: at 24 hours, 3: at 48 hours.
Isokinetic variables
changes in isokinetic variables: Peak torque, peak torque or force moment in extension and flexion in the different muscles involved and at the different measurement moments .It is measured in volts.
Time frame: Twice. One, before the consumption of the product under study and another after the consumption of the product. It was measured after 10 weeks.
Anthropometric variables
Weight (Kg), size (cm), BMI kg / m2. Perimeters (measured in cm): (waist, hip, waist / hip index, relaxed biceps, contracted biceps, medial thigh, twin or calf).Folds (mm) (tricipítal, subscapular, suprailiac anterior or supraspinal, abdominal, quadricipital or thigh, leg or calf medial, bicipital, iliocrestal). Diameters (cm) (radiocubital or wrist biestiloid, humeral or elbow bicpicondiolo, femoral or knee bicondiol).
Time frame: Two measurements. One, before the consumption of the product under study and another at 8 weeks of product consumption.
Impedancemetric variables
fat mass, total water, lean mass (measured in%), muscle mass, bone mass (kg), basal metabolism (KJ).
Time frame: Two measurements. One, before the consumption of the product under study and another at 8 weeks of product consumption.
liver safety variables
It is a blood test that measures the presence of some enzymes, proteins and bilirubin in the blood, with the aim of determining if there is any alteration in the liver. Enzyme GPT, GOT, Gamma GT, LDH, alkaline phosphatase and bilirubin (UI/L)
Time frame: It was measured before and after consumption of the supplement. In each of the times it was measured four times. Before performing the eccentric exercises, just after, at 24 and 48 hours later. One year