Decision Making, Daily Experiences, and Brain Activity in Young Adult Women

Mclean Hospital77 enrolled

Overview

The investigators are doing a study of women with and without binge-eating disorder to learn more about what happens when people engage in everyday decision-making activities. The investigators are interested in learning more about brain activity during everyday decision-making and how everyday decision-making relates to a variety of daily experiences. Examples of everyday decisions include deciding which product to buy, deciding what to eat for a snack, and deciding how to spend free time.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

SINGLE

Enrollment

Conditions

Binge-Eating Disorder

Interventions

Speaking ActivityBEHAVIORAL

Participants will engage in a speaking activity where they are given a topic to speak about.

Talking ActivityBEHAVIORAL

Participants will engage in a talking activity where they may talk about a topic of their choice.

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 40 YearsHealthy volunteers:

Medical Language ↔ Plain English

INCLUSION CRITERIA: Inclusion Criteria for All Participants: * Normal or corrected to normal vision and hearing * Verbal and written fluency in English * Right-handed * Body mass index of 20-35 kg/m\^2 Additional Inclusion Criteria for Participants with Binge-Eating Disorder: • DSM-5 binge-eating disorder EXCLUSION CRITERIA: Exclusion Criteria for All Participants: * Impaired cognition or other neurological/cognitive problems * Contraindications to MRI (e.g., certain metal implants, claustrophobia) * Currently/recently/potentially pregnant, seeking to become pregnant in the near future, or breastfeeding * Serious and/or unstable medical diseases and conditions, and certain other medical diseases and conditions * Recent low weight * Certain medications (e.g., insulin) * Current/recent frequent recreational drug use, or history of frequent recreational drug use in early adolescence * Extreme dietary limitations (e.g., veganism), pervasive food allergies, or limited exposure to popular snack foods * Current/recent suicidality * Current/recent changes in treatment for mental illness * Study-relevant research experience Additional Exclusion Criteria for Comparison Participants: * Personal history of eating disorders or recurrent binge eating * Personal history of any other mental illness, including serious substance use problems * First-degree relative with current or past eating or psychotic disorder * Significant recent change in weight Additional Exclusion Criteria for Participants with Binge-Eating Disorder: * Severe mental illness (e.g., psychotic disorder, severe agoraphobia) * Certain other current/recent mental illness, including severe substance use problems, that would limit study participation or safety * Recent anorexia nervosa spectrum disorder, avoidant-restrictive food intake disorder, or bulimia nervosa spectrum disorder

Locations (1)

McLean Hospital

Belmont, Massachusetts, United States

Outcomes

Primary Outcomes

Decision-making behavior (actual decisions)

Decisions (i.e., percent of goal-inconsistent decisions from challenge trials)

Time frame: Up to 1 hour post-intervention

Decision-related BOLD activation (reward regions-of-interest)

Percent change in blood oxygen level-dependent (BOLD) signal in response to decision making in regions involved in reward (e.g., nucleus accumbens, insula)

Time frame: Up to 1 hour post-intervention

Decision-related BOLD activation (executive function regions-of-interest)

Percent change in blood oxygen level-dependent (BOLD) signal in response to decision making in regions involved in executive function (e.g., dorsolateral prefrontal cortex, inferior frontal gyrus)

Time frame: Up to 1 hour post-intervention

Data from ClinicalTrials.gov

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