Clinical Relevance of the Reverse Lipopolysaccharide Transport Pathway in Patients With Acute Peritonitis

Centre Hospitalier Universitaire Dijon27 enrolled

Overview

When there is infection in the intra-abdominal area, bacteria secrete toxins that are absorbed by the peritoneum. These toxins then bind to lipoproteins (which carry cholesterol in the blood) and are eliminated by the liver. Phospholipid transfer protein (PLTP) is a protein that facilitates the binding of bacterial toxins to lipoproteins and thus their elimination. The objective of this study is to study the relationship between PLTP and the elimination of bacterial toxins in humans. A better understanding of the elimination of these toxins will lead to a better understanding of the disease. The ultimate objective is to improve the management of intra-abdominal infections.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Peritonitis

Interventions

blood samplesBIOLOGICAL

4 blood samples of 6 ml each: one before the surgical incision, one after the operation, one 4h after the operation and the last 24h after the operation.

Eligibility

Medical Language ↔ Plain English

Inclusion Criteria: * person who has given oral consent (patient or family member) * pre-operative SEPSIS criteria (qSOFA \>=2) or vasopressor or mechanical ventilation treatment * admitted to the operating room for suspected generalized secondary peritonitis Exclusion Criteria: * person not affiliated to national health insurance * person under legal protection (curatorship, guardianship) * person under court order * pregnant, parturient or breastfeeding woman * minor * immunosuppression (HIV infection, corticosteroid treatment \> 0.15 mg/kg/day prednisolone equivalent \> 2 weeks, immunosuppressive treatment, primary cellular immune deficiency) * decision to limit or stop therapy

Clinical Relevance of the Reverse Lipopolysaccharide Transport Pathway in Patients With Acute Peritonitis

Overview

Conditions

Interventions

Eligibility

Locations (1)

Outcomes

Primary Outcomes