2BALANCE: Cognitive-motor Dual-tasking in Persons with Vestibular Disorders

University Hospital, Ghent130 enrolled

Overview

The overall aim of this study is to elucidate the impact of a vestibular dysfunction on the cognitive and motor performance by means of an extensive test protocol, evaluating the vestibular, cognitive and motor function using single as well as dual-task paradigms.

The test protocol consists of five cognitive tasks, all assessing a different cognitive domain: executive function, working memory, processing speed, and visuospatial abilities (mental rotation and visuospatial memory). These cognitive tasks will be performed separately (in single task condition, while seated), as well as while performing different motor tasks (in dual-task condition). These motor tasks will also be performed in single task condition (without performing the cognitive tasks). The study consists of the establishment of normative age-related data for the single as well as dual-task protocol in healthy adults, age ranging from 18 to 65 years old (objective 1). Subsequently, the test protocol will be validated in persons with bilateral vestibulopathy (objective 2). Finally, a cross-sectional study in persons with unilateral vestibular impairment will take place, and the results on the single as well as dual-task components will be compared to normative data, as well as to persons with bilateral vestibulopathy (objective 3).

Study Type

OBSERVATIONAL

Enrollment

130

Conditions

Vestibular Diseases

Interventions

BehaviouralOTHER

Assessment of the 2BALANCE protocol: dual-task protocol consisting of a motor task, cognitive task, and motor-cognitive dual-tasks

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

For healthy controls: Exclusion Criteria: * Vestibular disorders or subjective dizziness complains (past or present) * Hearing loss * Mild Cognitive Impairment (Montreal Cognitive Assessment, MOCA) * Visual impairment (Snellen Chart) * Motor abnormalities (anamnestic questionnaire) For bilateral vestibulopathy (BV): Inclusion criteria: * Bilaterally reduced vestibular function, as defined by the Bárány Criteria for BV(Michael Strupp 2017): * the horizontal vestibulo-ocular reflex (VOR) gain should be \<0.6 bilaterally and/or * the sum of the maximal peak velocities of caloric response for stimulation with warm and cold water should be \<6◦/s bilaterally and/or * the horizontal angular VOR gain should be \<0.1 upon sinusoidal stimulation on the rotation test For unilateral vestibulopathy: Inclusion criteria: * the horizontal VOR gain should be \<0.6 unilaterally and/or * the slow component velocity of the caloric response should be below the age-dependent normative data unilaterally, established by Maes et al. (2010)

Locations (1)

University Hospital Ghent, departement otorhinolaryngology

Ghent, Belgium

Outcomes

Primary Outcomes

Stride length measured on the GAITRite Walkway (ProCare)

Stride length measured in centimeters on pressure sensitive mat

Time frame: 4 years

Step length measured on the GAITRite Walkway (ProCare)

Step length measured in centimeters on pressure sensitive mat

Time frame: 4 years

Stride width measured on the GAITRite Walkway (ProCare)

Stride width measured in centimeters on pressure sensitive mat

Time frame: 4 years

Step width measured on the GAITRite Walkway (ProCare)

Step width measured in centimeters on pressure sensitive mat

Time frame: 4 years

Step time measured on the GAITRite Walkway (ProCare)

Step time measured in seconds on pressure sensitive mat

Time frame: 4 years

Stride time measured on the GAITRite Walkway (ProCare)

Stride time measured in seconds on pressure sensitive mat

Time frame: 4 years

Velocity measured on the GAITRite Walkway (ProCare)

Velocity measured in centimeters per second on pressure sensitive mat

Time frame: 4 years

Surface (mm²) of the confidence ellipse which contains 90% of the center of pressure (COP) measured on the GymPlate (TechnoConcepts)

Confidence ellipse measured in millimeter² on force platform

Time frame: 4 years

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.