Differential Expression and Analysis of Peripheral Plasma Exosome miRNA in Patients With Myocardial Infarction

Xinhua Hospital, Shanghai Jiao Tong University School of Medicine10 enrolled

Overview

The aim of this study is to determine the miRNA expression profile in peripheral blood exosomes of patients with myocardial infarction and to investigate its relationship with myocardial infarction.

Collect exosomes in peripheral blood of patients with myocardial infarction, compare the expression of miRNA with healthy volunteers, find out the miRNAs with significant differences, and explore its relationship with the development of myocardial infarction.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Myocardial Infarction

Interventions

exosomeOTHER

Collect exosomes in peripheral blood of patients and extract miRNAs from them.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 100 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Age \> 18 years ST elevation by ECG diagnostic of STEMI Evidency of coronary occlusion in coronariography Signed informed consent Exclusion Criteria: * Patients who will undergo immediate PCI Pregnant and lactating women Patients with mental disorders Patients are using other experimental drugs; Refusal to provide informed.

Locations (1)

Ethics Committee of Xinhua Hospital

Shanghai, Shanghai Municipality, China

Outcomes

Primary Outcomes

Determination of differential expression of miRNA by second-generation sequencing technology

Time frame: Day 7

Secondary Outcomes

Diagnostic value of the differential microRNAs evaluate by qPCR in patients of myocardial infarction

Time frame: Day 7

Central Contacts

Bin He

CONTACT

021-25077828 hebinicu@139.com

Data from ClinicalTrials.gov

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