Efficacy of Individualized Rituximab in Maintaining Remission of Moderate and Severe Systemic Lupus Erythematosus

Inclusion Criteria: 1. Age, 18-65 years old, weight ≥ 40 kg, sex unlimited. 2. Clearly diagnosed with systemic lupus erythematosus. 3. There was at least one BILAG B or above score in the kidney, blood system and nervous system. 4. After standardized treatment with high dose glucocorticoid combined with immunosuppressants such as CTX,MMF or RTX, complete or partial remission of the disease was achieved (up to 1 BILAG B score, and at least 1 BILAG A or BILAG B score less than before). 5. Glucocorticoid: prednisone or the equivalent of prednisone less than or equal to 20 mg daily dose, and can be increased or decreased within 20 mg during the study. 6. Subjects are willing to participate in this study and sign informed consent voluntarily. 7. Prospective subjects agreed to use effective contraception throughout the study period. Exclusion Criteria: 1. Abnormal liver function: ALT or AST \>2ULN，or ALP or TBil \>1.5ULN 2. Severe cardiopulmonary disease; 3. Severe blood system disease 4. Patient with malignant tumor; 5. Concurrent infection：Subjects were hospitalized for infection or treated with parenteral antibiotics within 30 days before random; Hepatitis B surface antigen positive or active hepatitis, not treated with hepatitis B antivirus; T-SPOT positive or active tuberculosis, not treated with antituberculous therapy; Any positive in HCV-Ab, HIV-Ab, or TPPA ; 6. Pregnant patients or patients with recent fertility requirements; 7. Received cyclophosphamide treatment within 30 days before random; 8. For any other reason, the investigator believes that it is inappropriate to participate in the trial.