This is a cross-sectional pilot study of head and neck cancer survivors who have completed multi-modal treatment to assess and characterize the presence of distinct pain syndromes.
Primary objectives: * To correlate structural and functional MRI signature with one of three pain phenotypes in head and neck cancer survivors: 1) no pain, 2) central pain, and 3) nociceptive pain. * To correlate the presence of chronic systemic symptoms with pain phenotype Exploratory objectives: \- DNA, RNA, and plasma will be collected for genomic, transcriptomic, and proteomic studies. Results will be vertically integrated along with the results of clinical studies described within this protocol to identify targets for future correlative studies.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
DIAGNOSTIC
Masking
NONE
Enrollment
32
Delivers pressure to thumbnail for five seconds at a time
Scan of brain using Magnetic resonance imaging
Administration of questionnaires via computer
Vanderbilt-Ingram Cancer Center
Nashville, Tennessee, United States
Magnetic Resonance Imaging (MRI) to Correlate With One of Three Pain Phenotypes 1) no Pain, 2) Central Pain, 3) Nociceptive Pain
MRI scan of brain to measure response to stimulated pressure to thumbnail
Time frame: Approximately 8 weeks
Magnetic Resonance Imaging (MRI) to Correlate Presence of Chronic Systemic Symptoms With Pain Phenotype
MRI scan of brain to measure response to stimulated pressure to thumbnail
Time frame: Approximately 8 weeks
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.