Octreotide LAR in the Induction of Immunologic Response in NENs Patients

Inclusion Criteria: * Signed informed consent prior to initiation of any study-specific procedures or treatment, as confirmation of the patients awareness and willingness to comply with the study requirements. * Patients ≥18 years of age. * Patients with histologically confirmed well and moderately differentiated Neuroendocrine Tumors with Ki67 ≤ 20% (Ki67 must be quantified in percentage) and candidates for treatment with octreotide. * ECOG performance status (PS) of 0-2. * At least 28 days since prior the last radiation therapy or surgery. * Estimated life expectancy of ≥12 weeks. Exclusion Criteria: * Patients \< 18 years of age. * According to the current SmPC of the prescribed drug agent. * Previuos treatment with octreotide. * Psychiatric or addictive disorders or other conditions that, in the opinion of the investigator, would prevent the patient from meeting the study requirements. * Serious active infection requiring i.v. antibiotics and/or hospitalization at study entry. * Patients who are treated with any medicinal product that contraindicates the use of the study drug, may interfere with the planned treatment, affects patient compliance or puts the patient at high risk for treatment-related complications. * Pregnant or lactating females. Serum pregnancy test to be assessed within 7 days prior to study treatment start, or within 14 days with a confirmatory urine pregnancy test within 7 days prior to study treatment start. Women of childbearing potential (defined as inferior to 2 years after last menstruation and not surgically sterile) not using effective, non hormonal means of contraception (intrauterine contraceptive device, barrier method of contraception in conjunction with spermicidal jelly). Perimenopausal women must be amenorrheic for at least 12 months to be considered of non-childbearing potential * Patients with meningeal carcinomatosis * Patients with known positive HIV status