Safety and Effectiveness of MPCD Therapy on the Treatment of Malignant Pleural Effusion

Inclusion Criteria: 1. Histologically confirmed as lung cancer or breast cancer; 2. Cytologically or histologically confirmed MPE needing thoracocentesis treatment; 3. Without thoracocentesis treatment within 4 weeks; 4. ECOG PS score: 0-2 points; 5. Predicted life expectancy greater than 3 months; 6. 18 years ≤Age ≤80 years； 7. Bone marrow function: hemoglobin(HGB) ≥90g/L，white blood cells(WBC) ≥3.0×10\^9/L，absolute neutrophil count(ANC) ≥1.5×10\^9/L，platelets (PLT) ≥80×10\^9/L，international standardized ratio (INR) \<1.5; 8. Hepatic function：alanine aminotransferase(ALT) and aspartate aminotransferase(AST) ≤2.5×ULN，serum total bilirubin≤1.5× ULN; 9. Renal function：blood urea nitrogen(BUN) and serum creatinine(Cr) ≤1.5×ULN, or endogenous creatinine clearance rate(Ccr) ≥60mL/min; 10. Without other severe cardiac disease or respiratory disease; 11. The volunteers voluntarily join the study, sign informed consent, and have good compliance and follow-up. Exclusion Criteria: 1. Inappropriate to receive chemotherapy; 2. Women who are pregnant, preparing to be pregnant, breastfeeding; 3. Known or suspected hypersusceptibility to any agents used in the treatment protocol; 4. With severe cardiac disease, respiratory disease, liver disease, kidney disease, or diabetes; 5. With severe infection; 6. With severe encapsulated pleural effusion or intrathoracic tissue adhesion which is inappropriate to receive thoracocentesis; 7. With cognitive impairment or low compliance; 8. Participating in other clinical trials within 4 weeks; 9. Undergoing immunotherapy within 3 months; 10. Other conditions considered to be inappropriate to be enrolled by the investigator.