Sleep and Girls' Emotions Study

University of Oregon34 enrolled

Overview

This study evaluates whether increasing sleep duration can increase neural and behavioral response to rewards and decrease depressive symptoms in 18- to 22-year-old women with insufficient sleep and depressive symptoms.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

SINGLE

Enrollment

Conditions

Depression

Interventions

Typical sleep opportunityBEHAVIORAL

Typical sleep opportunity with consistent sleep timing for 1 week

Extended sleep opportunityBEHAVIORAL

Extended sleep opportunity by 90 min per night with consistent sleep timing for 1 week

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 22 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Insufficient sleep (total sleep time \< 8 hours per night, with sleepiness scores ≥ 6 on the Epworth Sleepiness Scale OR ≥ 16 on the PROMIS Sleep Related Impairment Scale) * Symptoms of depression (≥ 15 on the Center for Epidemiological Studies for Depression Scale) Exclusion Criteria: * Current insomnia, hypersomnia, sleep disordered breathing, sleep movement disorder, or circadian rhythm disorder * History of head injury with loss of consciousness within the past two years * History of head injury with loss of consciousness two or more years ago and meet criteria for post concussion syndrome * Neurological disorder * Use of psychiatric medications * Current psychotic symptoms * Active suicidal ideation * Conditions that are contraindicated for MRI (e.g., ferromagnetic material in the body) * Meet criteria for current substance use disorder with greater than mild severity

Locations (1)

University of Oregon

Eugene, Oregon, United States

Outcomes

Primary Outcomes

Depressive symptoms

Center for Epidemiological Studies Depression Scale score. The CESD-R is a 20-item measure of the frequency of depressive symptoms, with each item rated on a scale from 0 (not at all or less than one day) to 5 (nearly every day). Total scores range from 0 to 100, with higher scores indicating greater number and frequency of depressive symptoms.

Time frame: 1 week

Reward-related brain function

BOLD fMRI response during Reward Guessing Task

Time frame: 1 week

Sleep duration

Mean actigraphy-measured sleep duration

Time frame: 1 week

Secondary Outcomes

Positive affect

International Positive and Negative Affect Scale Short Form - Positive Affect score. The I-PANAS-SF is a 10-item scale that asks participants to rate the extent to which 5 positive and 5 negative adjectives describe them on a scale of 1 (never) to 5 (always). Scores for each positive adjective are summed to produce a Positive Affect (PA) score ranging from 5 to 25, with higher scores indicating more positive affect.

Time frame: 1 week

Negative affect

International Positive and Negative Affect Scale Short Form - Negative Affect score. The I-PANAS-SF is a 10-item scale that asks participants to rate the extent to which 5 positive and 5 negative adjectives describe them on a scale of 1 (never) to 5 (always). Scores for each negative adjective are summed to produce a Negative Affect (PA) score ranging from 5 to 25, with higher scores indicating more negative affect.

Time frame: 1 week

Reward effort

Effort Expenditure for Rewards Task score

Data from ClinicalTrials.gov

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