This study evaluates whether increasing sleep duration can increase neural and behavioral response to rewards and decrease depressive symptoms in 18- to 22-year-old women with insufficient sleep and depressive symptoms.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
SINGLE
Enrollment
34
Typical sleep opportunity with consistent sleep timing for 1 week
Extended sleep opportunity by 90 min per night with consistent sleep timing for 1 week
University of Oregon
Eugene, Oregon, United States
Depressive symptoms
Center for Epidemiological Studies Depression Scale score. The CESD-R is a 20-item measure of the frequency of depressive symptoms, with each item rated on a scale from 0 (not at all or less than one day) to 5 (nearly every day). Total scores range from 0 to 100, with higher scores indicating greater number and frequency of depressive symptoms.
Time frame: 1 week
Reward-related brain function
BOLD fMRI response during Reward Guessing Task
Time frame: 1 week
Sleep duration
Mean actigraphy-measured sleep duration
Time frame: 1 week
Positive affect
International Positive and Negative Affect Scale Short Form - Positive Affect score. The I-PANAS-SF is a 10-item scale that asks participants to rate the extent to which 5 positive and 5 negative adjectives describe them on a scale of 1 (never) to 5 (always). Scores for each positive adjective are summed to produce a Positive Affect (PA) score ranging from 5 to 25, with higher scores indicating more positive affect.
Time frame: 1 week
Negative affect
International Positive and Negative Affect Scale Short Form - Negative Affect score. The I-PANAS-SF is a 10-item scale that asks participants to rate the extent to which 5 positive and 5 negative adjectives describe them on a scale of 1 (never) to 5 (always). Scores for each negative adjective are summed to produce a Negative Affect (PA) score ranging from 5 to 25, with higher scores indicating more negative affect.
Time frame: 1 week
Reward effort
Effort Expenditure for Rewards Task score
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Time frame: 1 week
Reward-related functional connectivity
BOLD fMRI psychophysiological striatal-medial prefrontal cortex interaction
Time frame: 1 week