This systematic review and meta-analysis is aimed to assess the effect of commonly consumed viscous fibers on blood lipids including LDL-C, non-HDL-C, and ApoB.
Medline, Embase, CINAHL, and the Cochrane Central databases were searched through May 13, 2019. Three independent reviews extracted data and assessed risk of bias. Randomized controlled trials that assessed the effect of barley b-glucan, oat b-glucan, konjac glucomannan (KJM), psyllium, guar gum, and pectin, with a study duration of ≥ 3 weeks, in adults with or without hypercholesterolemia were included. Data were pooled using the generic inverse variance method with random effects models and expressed as mean differences with 95% confidence intervals. Heterogeneity was assessed by the Cochran Q statistic and quantified by I2 statistic. Overall quality of the evidence was assessed using the GRADE (Grading of Recommendations Assessment, Development, and Evaluation) approach.
Study Type
OBSERVATIONAL
Enrollment
7,845
ex. barley b-glucan, oat b-glucan, konjac glucomannan, psyllium, guar gum, and pectin
Clinical Risk Factor and Modification Centre
Toronto, Ontario, Canada
LDL-Cholesterol
Time frame: ≥ 3 weeks
non-HDL-Cholesterol
Time frame: ≥ 3 weeks
ApoB
Time frame: ≥ 3 weeks
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