Prospective, monocentric, non-interventional study in patients placed on extracorporeal membrane oxygenation (ECMO)
Our hypothesis is that ECMO initiation is responsible for a severe decrease of antithrombin level in a high proportion of patients who develop heparin resistance.
Study Type
OBSERVATIONAL
Enrollment
50
Blood sample collection from a peripheral catheter at ECMO initiation (H0), then 2h, 6h, 12h, 24h and daily from day 2 to day 7 or at ECMO discontinuation
CHU Rennes
Rennes, France
To study antithrombin level from during the first 24h after ECMO initiation
Blood sample at ECMO initiation (H0), then 2h, 6h, 12h, 24h and daily from day 2 to day 7 or at ECMO discontinuation
Time frame: Day 7
To study antithrombin level 24h after initialization of ECMO
Blood sample at 24h
Time frame: Hour 24
To study the prevalence of antithrombin (AT) deficiency (≤70%) at each time point (from H0 to day 7)
Blood sample
Time frame: Day 7
To study relationship between antithrombin level and heparin resistance
Blood sample
Time frame: Day 7
To study relationship between antithrombin level and thrombin generation test
Blood sample
Time frame: Day 7
To study clinical factors associated with AT deficiency
Blood sample
Time frame: Day 7
To describe clinical evolution of patients according to initial AT level
Blood sample
Time frame: Hour 0
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