Multiple Applications of ExpressGraft-C9T1 Skin Tissue as a Treatment for Diabetic Foot Ulcers

Volunteers will be consented. Then there will be a run-in period for the doctor to run some tests. If the tests show the study would be good for the patient, the doctor will enroll them as participants in the trial. Inclusion Criteria: To be considered for inclusion, a participant: * Agrees to practice birth control for the duration of the study * Has documented Type 1 or Type 2 diabetes and an HbA1C score of 10 or below * Has protocol-defined sufficient blood pressure and flow to the foot * Has stable medications for 2 weeks before treatment (other than diabetes medications or antibiotics) * Is able and willing to attend scheduled visits and comply with study procedures * If a smoker, agrees to try quitting and will accept counseling for it (Cohorts 2 and 3 only) * Has documented informed consent for study enrollment * Has had an uninfected, appropriately-sized diabetic ulcer on the foot for at least 4 weeks but not more than 1 year Exclusion Criteria: The doctor may not consider for inclusion a participant who: * Is pregnant, nursing, or a prisoner * Has had osteomyelitis in the foot with the ulcer in the last 30 days * Has a history of poor compliance * Has received drugs or therapies not allowed per protocol * Has used an investigational product within the last 60 days * Has ever received therapy for the study ulcer with any cell and/or tissue product (CTP) * Has a study ulcer in a condition not appropriate for the study * Has a medical condition or history that, per protocol or in the opinion of the study doctor, might put the safety of the participant in danger