This early phase I trial studies how well transcranial direct current stimulation works in reducing pain in cancer patients with chemotherapy induced peripheral neuropathy. Transcranial direct current stimulation is used for patients with brain injuries such as strokes as well as for mental health issues such as depression and may help to control pain in cancer patients with chemotherapy induced peripheral neuropathy.
PRIMARY OBJECTIVES: I. To evaluate the efficacy of transcranial direct current stimulation (tDCS) in reducing chemotherapy induced painful peripheral neuropathy (CIPPN). Ia. Evaluate the change in pain scores Ib. Assess for changes in other symptoms (i.e insomnia, feeling of well-being, depression and anxiety). SECONDARY OBJECTIVES: I. To evaluate the following with the treatment of tDCS: Ia. Assess for changes in using pain medications. Ib. Assess for changes in functioning (daily activities). Ic. Assess for changes in quality of life. Id. Assess for changes in neuropathy. Ie. Assess overall satisfaction with the tDCS treatment. TERTIARY OBJECTIVES: I. To evaluate tDCS treatment related side-effects. OUTLINE: Patients undergo tDCS once daily (QD) over 20 minutes 5 days each week (Monday-Friday) for 3 weeks. After completion of study treatment, patients are followed up weekly for 3 weeks and at 4-6 weeks.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
SUPPORTIVE_CARE
Masking
NONE
Ancillary studies
Ancillary studies
Undergo tDCS
M D Anderson Cancer Center
Houston, Texas, United States
Change in chemotherapy induced peripheral neuropathy pain score
The Pain inventory is an assessment of pain level on a 11-point numeric rating scales (0=none to 10=worst).
Time frame: Baseline up to final day of treatment (3 weeks)
Change in total opioid requirement (morphine equivalent daily dosage)
Will be summarized using descriptive statistics including mean, standard deviation, median, range, and CIs.
Time frame: Baseline up to 4-6 weeks post-treatment
Change in cancer related symptoms
We will analyze each patient's Pain Management Center Follow-Up/ Progress Notes and Standardize questionnaire which includes the assessment of the aforementioned symptoms on a 11-point numeric rating scales (0=none to 10=worst).
Time frame: Baseline up to 4-6 weeks post-treatment
Change in functioning of Daily Activities
We will analyze each patient's Pain Management Center Follow-Up/ Progress Notes and Standardize questionnaire which includes the assessment of the aforementioned symptoms on a 11-point numeric rating scales (0=none to 10=worst).
Time frame: Baseline up to 4-6 weeks post-treatment
Change in quality of life questionnaire
We will analyze each patient's Pain Management Center Follow-Up/ Progress Notes and Standardize questionnaire which includes the assessment of the aforementioned symptoms on a 11-point numeric rating scales (0=none to 10=worst).
Time frame: Baseline up to 4-6 weeks post-treatment
Incidence of adverse events
Frequency counts and percentages will be documented.
Time frame: Up to 4-6 weeks post-treatment
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