Graves' disease (GD) is one of organ specific autoimmune diseases, the pathogenesis is not elucidated.Natural Killer (Natural Killer, NK) cells is a kind of important immune regulator, several abnormalities of NK cell function and number in GD patients have been described in the investigators' previous study. It is remain unclear whether the NK cell disfunction is a consequence of GD.Based on the investigators' previous study, the investigators plan to monitor NK cell function in participants in the whole course of disease, analyze the association with relevant factors, such as thyroid function, immune state or treatment,to find out influences of thyroid hormones and thyroid receptor antibody affecting the function of NK cell. The investigators will reveal whether the disfunction of NK cell secondary to GD abnormal thyroid function and/or immune disorders, and realize the mechanics.
Study Type
OBSERVATIONAL
Enrollment
200
Shandong Provincial Hospital
Jinan, Shandong, China
The number and function of NK cells changes of hyperthyroidism
Flow cytometry used to measure the related changes of NK cells in hyperthyroidism
Time frame: measured after 2 years of follow-up
Changes in serum levels
Detection of related cytokines by ELISA
Time frame: measured after 2 years of follow-up
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.