This study is being done to help further understand how MR-guided adaptive RT in conjunction with the Integrated Magnetic Resonance Linear Accelerator (MRL) can improve patient outcomes. This study will include participants who will be receiving radiotherapy using the MRL machine to target their cancer more precisely. Participants will be asked to have a few extra MR scans taken during their RT planning and to complete a few quality of life questionnaires.
Study Type
OBSERVATIONAL
Enrollment
500
Princess Margaret Cancer Centre
Toronto, Ontario, Canada
Local, regional and distant tumor control rates
Refine our understanding of clinical scenarios where MRgART with the MRL improves patient outcomes and translate this new knowledge and new treatment approach to widespread clinical practice through the development and validation of efficient, cost-effective treatment processes.
Time frame: Up to 5 years post-radiotherapy
Disease-free and overall survival rates
Refine our understanding of clinical scenarios where MRgART with the MRL improves patient outcomes and translate this new knowledge and new treatment approach to widespread clinical practice through the development and validation of efficient, cost-effective treatment processes.
Time frame: Up to 5 years post-radiotherapy
Complication rates measured using the Common Toxicity Criteria for Adverse Events
Refine our understanding of clinical scenarios where MRgART with the MRL improves patient outcomes and translate this new knowledge and new treatment approach to widespread clinical practice through the development and validation of efficient, cost-effective treatment processes.
Time frame: Within 3 months of completing treatment
Patient experience and anxiety related to MR imaging and adaptive RT with the MR
Evaluate the patient experience during adaptive RT with the MRL using the Magnetic Resonance Imaging-Anxiety Questionnaire (MRI-AQ) which measures patient anxiety and tolerability of MR-related procedures
Time frame: Immediately after first MRL treatment visit
Patient experience and anxiety related to MR imaging and adaptive RT with the MR
Evaluate the patient experience during adaptive RT with the MRL using the EORTC satisfaction with cancer care core questionnaire (EORTC PATSAT-C33) and specific complementary outpatient module (EORTC OUT-PATSAT7)
Time frame: Immediately after last MRL treatment visit
Patient experience and anxiety related to MR imaging and adaptive RT with the MR
Evaluate the patient experience during adaptive RT with the MRL using -The EORTC QLQ C30 quality of life questionnaire
Time frame: d prior to starting treatment with the MRL, immediately after the last MRL treatment, at the first follow-up visit and annually thereafter during follow-up (up to 5 years post treatment)
Patient experience and anxiety related to MR imaging and adaptive RT with the MR
Evaluate the patient experience during adaptive RT with the MRL using complete the Edmonton Symptom Assessment Scale revised version (ESAS-r)
Time frame: each ambulatory care and radiation treatment review clinic visit (up to 5 years post treatment)
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