Clinical Trial of Dose-tolerance, Pharmacokinetics and Iodine Uptake For rhTSH In Post-thyroidectomized Patients

Inclusion Criteria: * Pathological diagnosis of differentiated thyroid cancer, including papillary thyroid cancer (including papillary carcinoma follicular subtype), follicular thyroid cancer, and Hurthle cell thyroid cancer; * Screening ages 18-75 (including 18 Age and 75 years old, male or female; * Weight 45kg-80kg (including 45kg and 80kg, limited to the dose escalation test); * Complete thyroidectomy or near total resection, and plan to start 131I diagnosis or ablation Patients * Serum TSH ≤ 0.5 mU/L; * Women of childbearing age are HCG-negative and must continue contraception until more than 3 months after the end of the trial; * Subjects (including partners) from 2 weeks prior to dosing to the last study drug There is no pregnancy plan within 3 months after the drug and voluntary effective contraceptive measures are taken. For specific contraceptive measures, see Appendix 3; * Normal ECG. Intermittent atrial premature beats, supraventricular tachycardia (SVT) or supraventricular block-independent PR interval abnormalities, right bundle branch block, mild sinus bradycardia (asymptomatic, and no treatment required) Can be grouped; * Low iodine diet before enrollment for more than 4 weeks; * Patients are voluntarily enrolled, and written informed consent forms can be used for treatment and visits as required by the program. Exclusion Criteria: * Patients who are not eligible for THST withdrawal due to pituitary disease or other diseases; * Patients not eligible for 131I diagnosis or treatment; * Any significant clinical and laboratory abnormalities (eg, severe cardiopulmonary disease, hepatic insufficiency, renal function) Incomplete, congestive heart failure, advanced lung disease or advanced cardiovascular and cerebrovascular disease, active infection); * Hypertensive patients who cannot be reduced to the following range due to medical treatment (systolic blood pressure \<140 mmHg, diastolic blood pressure \<90 mmHg); * Patients who have used any water-soluble radiographic contrast agent intravenously within 4 weeks before administration; * Patients who underwent intrathecal iodine angiography or gallbladder iodine imaging within 3 months prior to administration; * taken/eaten within 4 weeks prior to administration Drugs/foods that affect iodine uptake or metabolism, such as multivitamins, glucocorticoids, diuretics, lithium, thiouracil, tazobactam, algae, iodine (except thyroid hormone replacement therapy); * before administration Stroke, unstable angina (CCS class II or higher), atrial fibrillation or medication (within beta blocker or digoxin) within 6 months Patients with a history of arrhythmia; * pregnant or lactating women; * a history of drug use and/or alcohol abuse within 3 months prior to dosing; * patients who are allergic to rhTSH and its excipients; * patients with positive infection-related tests : Includes hepatitis C and AIDS; * Participated in any drug or medical device clinical trial within 1 month prior to the trial; * Those who were unable to participate in the trial as judged by the investigator.