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Testicular Function After Testicular Torsion

N/AUnknownNCT04137965
Herlev and Gentofte Hospital140 enrolled

Overview

The purpose of this study is to evaluate testicular function measured as testosterone level and semen quality.

Men having undergone surgery for testicular torsion between 01.01.2003 - 12.31.2012 will receive a invitation to participate in this study. It is expected that 110 patients can be identified and about 65% of them will participate. These men will undergo a andrological evaluation, deliver a semen sample, have a blood sample taken and undergo a testicular ultrasound. Control group: Men attending the fertility counseling at Herlev hospital will be offered participation in this study. The fertility counseling demands that men who contact the clinic have never had their sperm analyzed, have not tried to get pregnant with their partner for more than a year and that they have no prior knowledge of their fertility. Primary endpoint: * Semen quality measured as sperm concentration * Total testosterone level Secondary endpoint: Semen parameters * Semen volume (ml) * Sperm concentration (x 106/ml) * Sperm motility (%) (både klasse AB og ABC) * sperm morphology * IgA-bound spermatozoa (%) * IgG-bound spermatozoa (%) Hormones * FSH * LH * PRL * Testosterone * Estradiol * Inhibin B * Insulin-like peptide 3 * SHBG Data points: * Paternity * Time to pregnancy * Partner (yes/no) * Any fertility treatment? * Pain? (VAS score) * Symptoms of testesterone deficiency symptoms * Andrological evaluation * Testicular ultrasound * Testicular torsion events in the family * Date of surgery * Date of follow up meeting * Surgery details

Study Type

OBSERVATIONAL

Enrollment

140

Conditions

Testicular TorsionSpermatic Cord Torsion

Eligibility

Sex: MALEMin age: 18 Years
Medical Language ↔ Plain English
Inclusion Criteria: * Men with a verified testicular torsion operated at Herlev and Gentofte hospital between 01.01.2003 and 12.31.2012 Exclusion Criteria: * Retentio testis * Varicocele * Previous treatment with chemo- or radiation therapy * Genetic disposition for infertility * Anejculation * Retrograde ejaculation

Locations (1)

Department of Growth and Reproduction

Copenhagen, Denmark

RECRUITING

Outcomes

Primary Outcomes

Sperm concentration

Amount of motile sperm cells (\* 10\^6)

Time frame: 8-17 years after surgical intervention

Testosterone level

ng/ml

Time frame: 8-17 years after surgical intervention

Secondary Outcomes

Semen parameters as an indicator of overall testicular exocrine function

Compared with results from control group

Time frame: 8-17 years after surgical intervention

Hormone level as an indicator of testicular endocrine function

Follicle stimulating hormone, luteinizing hormone, prolactin, testosterone, estradiol, inhibin B, sex hormone-binding globulin, albumin

Time frame: 8-17 years after surgical intervention

MAR test result correlated to the type of surgery

MAR test of sperm cells

Time frame: 8-17 years after surgical intervention

Difference in sperm morphology and motility correlated to the type of surgery and compared to control group

Morphology and motility (%)

Time frame: 8-17 years after surgical intervention

Paternity as a measure of fertility

Number of kids if any.

Time frame: 8-17 years after surgical intervention

Central Contacts

Frederik M Jacobsen

CONTACT

38688949frederik.moeller.jacobsen.01@regionh.dk

Trine Møller Rudlang, MD

CONTACT

Trine.møller.rudlang@regionh.dk
Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.