Comparison Of Dexmedetomidine, Fentanyl And Lignocaine In Attenuation Of Hemodynamic Response To Direct Laryngoscopy And Intubation In Patient Undergoing Laparoscopic Cholecystectomy
Direct laryngoscopy and intubation are painful stimulus that activates sympathoadrenal discharge which results in intense cardiovascular reflex i.e. tachycardia and hypertension. In this study we will compare effects of intravenous dexmedetomidine, fentanyl and lidocaine for attenuation of these reflexes in patient undergoing laproscopic cholecystectomy. how these agents will effect hemodynamic response during pneumoperitoneum. Tertiary objective will be to observe sedation, perioperative complications and recovery in these patients.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
SINGLE
Enrollment
30
intravenous dexmedetomidine 0.06mg/kg in 100ml normal saline 0.9% over 10minutes.
intravenous fentanyl at 2mcg/kg in 100ml saline over 10 minutes in induction room.
intravenous lidocaine 1.5mg/kg in 100ml saline over 10 minutes in induction room.
DUHS, Civil hospital Karachi (CHK)
Karachi, Sindh, Pakistan
RECRUITINGDUHS, Civil hospital Karachi (CHK)
Karachi, Sindh, Pakistan
RECRUITINGsystolic blood pressure
hermodynamic response (Top number will be assessed of blood pressure)
Time frame: at induction
Diastolic blood pressure
hermodynamic response (bottom number will be assessed of blood pressure)
Time frame: at induction
mean atrial pressure
Hemodynamic responses (average blood pressure in an individual during a single cardiac cycle)
Time frame: at induction
Heart rate
Hemodynamic responses (average heart rate beats a minute)
Time frame: at induction
Oxygen saturation (SpO2)
Hemodynamic responses) (arterial oxy-hemoglobin saturation is measured non-invasively by a finger pulse oximeter or handheld pulse oximeter,
Time frame: at induction
Sedation assessment
Ramsey score use for sedation, it consist of 1-6 where 6 indicates worst(no response) and 6 indicates good response
Time frame: at 10 minutes post operative
Recovery assessment
Aldret score use for recovery assessment, it consist of 0-10 point where 0 indicates worst(no response) and 10 indicates good response
Time frame: at 10 minutes post operatively
Complications
Cough, Laryngospasm, Bradycardia, Regugitation, PONV, Hypertention, Hypotension
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Time frame: 1 week Post-operative(Operation -discharge)