Olfactory Function and Olfactory Bulb Volume in Acromegaly Patients

Bezmialem Vakif University40 enrolled

Overview

A prospective, controlled, single blinded study was planned. 20 patients with Acromegaly (Acromegaly Group) and 20 healthy subjects (Control Group) were planned to include in the study. Connecticut Chemosensory Clinical Research Center (CCCRC) test was applied to evaluate olfactory functions. Olfactory bulb(OB) volumes were measured with a 1.5 T General Electric Signa Excite MRI scanner.

Acromegaly patients were assessed at the Endocrinology Department for their clinical symptoms, and the nasal examination and olfactory evaluation were done at the Department of Otorhinolaryngology. OB volume was evaluated by a single blinded radiologist. Control group patients that had similar demographical characteristics with the Acromegaly Group were recruited in the study. The CCCRC test is composed of n-butanol odor threshold test and odor identification test. Olfactory tests were scored out of 7 (0: worst, 7: best olfaction) and mean score was calculated as the total CCCRC test score. OB measurements were done individually on the right and left olfactory bulbs and the mean OB volume was calculated in cubic millimeters.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

OTHER

Masking

SINGLE

Enrollment

Conditions

Acromegaly Olfactory Disorder

Interventions

OB volumeOTHER

The mean OB volume was calculated in cubic millimeters and compared between the two groups.

CCCRC testOTHER

CCCRC test was done for olfactory function assessment and compared between the two groups.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Acromegaly diagnosis * Healthy subjects that had no nasal problems Exclusion Criteria: * Previous nasal surgery * Acute respiratory tract infection * Nasal polyposis * Nasal pathologies that causes nasal obstruction

Locations (1)

Bezmialem Vakif University

Istanbul, Fatih, Turkey (Türkiye)

Outcomes

Primary Outcomes

Olfactory bulb (OB) volume

Measurements were done individually on the right and left OB, and the mean OB volume was calculated in cubic millimeters. The mean OB volume was compared between the two groups.

Time frame: 18 months

CCCRC test results

Olfactory tests were scored out of 7 (0: worst, 7: best olfaction) and mean score was calculated as the total CCCRC test score. The mean score was compared between the two groups.

Time frame: 18 months

Data from ClinicalTrials.gov

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