Evaluate Safety, Pharmacokinetics and Pharmacodynamics of BBT-877 in Healthy Japanese Male

Inclusion Criteria: 1. Signed the informed consent form as described in Appendix 3 which includes compliance with the requirements and restrictions listed in the informed consent form (ICF) and in this protocol 2. Healthy male 18 to 55 years of age inclusive at the time of signing the informed consent form 3. Continuous non-smoker who has not used nicotine-containing products for at least 3 months prior to dosing and throughout the study. 4. Overtly healthy as determined by medical evaluation including medical history, physical examination, clinical laboratory tests 5. Body mass index (BMI) within 18 to 30.0 kg/m2 (inclusive) and body weight not less than 50 kg 6. Blood pressure (after supine for 5 minutes) between 90 and 140 mmHg systolic, inclusive, and no higher than 90 mmHg diastolic. 7. A 12-lead electrocardiogram (ECG) consistent with normal cardiac conduction and function. 8. Must agree to use contraception as detailed in Appendix 5 of this protocol during the treatment period and for at least 90 days after dosing of study treatment and refrain from donating sperm during this period 9. Be first generation Japanese. Exclusion Criteria: 1. Has a history of or current clinically significant medical illness that the investigator considers should exclude the subject or that could interfere with the interpretation of the study results. 2. Clinically significant abnormal values for hematology, clinical chemistry, or urinalysis at screening and Day -1 as deemed appropriate by the investigator 3. Clinically significant abnormal physical examination, vital signs or 12 lead ECG at screening and Day -1 as deemed appropriate by the investigator 4. Has donated blood or had a significant blood loss (≤500 mL) within 8 weeks of Day 1 or history of anemia or history of decreased red blood cells (RBC). 5. Donated plasma within 7 days of Day -1 6. Estimated creatinine clearance \<80 mL/min 7. Liver function tests (serum alkaline phosphatase \[ALP\], aspartate transaminase \[AST\], alanine aminotransferase \[ALT\]) and serum bilirubin (total and direct) 1.2 times above the upper limit of normal (ULN) at Screening or Day -1. 8. Baseline hemoglobin, hematocrit, red blood cell count below the lower limit of normal at Screening and Day -1. 9. Has a history of human immunodeficiency virus (HIV) antibody positive, or tests positive for HIV; has a history of hepatitis B surface antigen (HBsAg) or hepatitis C antibody (anti-HCV) positive, or other clinically active liver disease, or tests positive for HBsAg or anti-HCV at Screening. 10. History of drug or alcohol abuse according to Diagnostic and Statistical Manual of Mental Disorders (4th edition) criteria within 5 years before screening or positive test result(s) for alcohol and/or drugs of abuse at screening and Day -1. 11. Positive cotinine test at Screening and Day -1. 12. History of presence of hypersensitivity or idiosyncratic reaction to the study drug(s) or related compounds.