DAnalysis of the Distribution of Adrenal Steroids in a Control Population

University Hospital, Lille60 enrolled

Overview

This is a biomedical research study on the determination of adrenal steroids. It has been proposed in recent years as a tool for the diagnostic orientation of an adrenal pathology. The main objective is to analyze the distribution of blood and urinary adrenal steroid values in a population of 60 controls. The secondary objective is to establish reference values for each of these parameters, if their distribution permits, and to study the possible link between the blood pressure level, the orthostatism state, the potassium level and these adrenal steroids.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Adrenal Disease

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Negative blood pregnancy test * Normosalt diet * Men and women ≥ 18 years * Being able and willing to give written informed consent Exclusion Criteria: * Personal history of diabetes, high blood pressure, adrenal pathologies. * Family history of adrenal pathologies. * Taking of the following drugs: Antihypertensives drugs: ACE inhibitor, Angiotensin II receptor, beta-blocker, thiazide diuretic, loop diuretic, anti-aldosterone, dihydropyridine-type calcium antagonist. * Hormone replacement therapy, cyproterone acetate * NSAID (except occasional intake), corticosteroid * Antidepressant: serotonin reuptake inhibitor (paroxetine, fluoxetine, sertraline, citalopram) * Contraception or estrogen / progestin treatment (progestins only allowed) * Not be able to keep standing position.

Locations (1)

CHRU, Hôpital Claude Huriez

Lille, France

Outcomes

Primary Outcomes

difference of the distribution of blood steroid values in a population control group

The value will be measured by mass spectrometry coupled with liquid chromatography (HPLC-MS) and 16 global parameters will be analyses (B, 18-OH B, DOC, 18-OH DOC, S, F, 18-OH F, 17-OH progesterone, 21-desoxycortisol, delta 4 androstenedione, 17OHpregnenolone, aldosterone, SDHA, E, testosterone, estradiol

Time frame: At baseline

difference of the distribution of urinary steroid values in a population control group

The value will be measured by mass spectrometry coupled with liquid chromatography (HPLC-MS) and 6 global parameters will be analyses (E, F, THF, aTHF, THE, aldosterone)

Time frame: At baseline

Secondary Outcomes

Blood pressure taken while sitting, lying or standing

Time frame: At baseline

blood concentration of kaliemia

Time frame: at baseline

Data from ClinicalTrials.gov

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