This study will help determine if a short course of radiation therapy is effective to treat rectal cancer in older patients. A shorter course of radiation treatment may be better tolerated than a longer course or surgery for the treatment of rectal cancer in the elderly.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
2
25 Gray in 5 fractions over 5-7 days
James P. Wilmot Cancer Center at University of Rochester Medical Center
Rochester, New York, United States
Progression-free survival
Progression will be defined as Radiologic response from MRI or CT scans using RECIST v1.1 criteria.
Time frame: 5 years
Number of participants who experience a grade 2 adverse event
CTCAE V4.0 will be used to determine the grade 2 AE.
Time frame: week 5
Number of participants who received surgery for their cancer
Time frame: 5 years
Number of participant who experience metastatic disease
MRI or endoscopy will be used to track metastasis to other parts of the body
Time frame: 5 years
Change in Mean quality of life
Quality of life will be assessed using the Low Anterior Resection Syndrome Score Questionnaire. Scores range from 0-42 points with higher scores indicating worse outcome.
Time frame: baseline to 24 months
Change in Mean functional status
Quality of life will be assessed using the Low Anterior Resection Syndrome Score Questionnaire. Scores range from 0-42 points with higher scores indicating worse outcome.
Time frame: baseline to 24 months
Number of participants with improved symptoms
Symptoms will be documented by the treating physician at each clinical visit for 5 years.
Time frame: 5 years
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