Evaluation of Duloxetine and Innovative Pelvic Floor Muscle Training in Women With Stress Urinary Incontinence

Inclusion Criteria: * Woman's willing to provide written informed consent * Women over 18 years that experience uncomplicated stress urinary incontinence * Score of the International Consultation on Urinary Incontinence Questionnaire ≥ 14 points * Symptoms of urinary incontinence for at least 3 consecutive months * Have at least seven urinary incontinence episodes per week * Degree of pelvic organ prolapse ≤ 2 stage * Willingness to accept the randomization process and fully participate in tests Exclusion Criteria: * Recent use of any pharmacologic agent used to treat symptoms of urinary incontinence in the past six months * History of anti-incontinence surgery in the past 12 months * Use of onabotulinumtoxinA for the treatment of urinary incontinence in the past 12 months * History of pelvic prolapse repair or urethral surgery in the past 12 months * History of pelvic floor muscle training in the past 12 months * History of interstitial cystitis or bladder-related pain * Chronic severe constipation * Clinically significant renal or hepatic impairment * Clinically significant heart impairment * Pregnant woman, lactating, or actively trying to become pregnant * Non-compliance with limitation of duloxetine treatment for mixed urinary incontinence * Positive urinary tract infection * Use of rehabilitation aids (pessary, urethral plugs, vaginal beads, etc.) * Use of antidepressant therapy * Insufficient understanding of pelvic floor exercises and/or omitting exercises * Participation in any clinical study in the past six months