The investigators are studying whether metabolic abnormalities in calf (leg) muscle in older people with and others without HIV are associated with decreased abilities to exercise.
This research is being done to better understand why some older people living with HIV experience more fatigue and difficulty exercising than older people without HIV. This is important because fatigue and problems exercising are predictors of disability and hospitalization in older individuals. We will use non-invasive magnetic resonance imaging (MRI) and spectroscopy (MRS) of the leg muscle to measure muscle metabolites and fat content, as well as blood samples measures levels of inflammation.
Study Type
OBSERVATIONAL
Enrollment
200
Johns Hopkins Hospital
Baltimore, Maryland, United States
RECRUITINGMaximal mitochondrial oxidative capacity (VmaxPCr)
Maximal oxidative capacity of leg muscle measured by 31P Magnetic Resonance Spectroscopy (MRS)
Time frame: Baseline
Rate of PCr decline during plantar flexion exercise
Time frame: Baseline
Six minute walk distance
Time frame: Baseline
Skeletal muscle fat content
Time frame: Baseline
Gait speed
Time frame: Baseline
Frailty status (as measured by the Fried Frailty Index)
Fried frailty index described in J Gerontol A bill Sci-Fi Med Sci-Fi 2001;56:M146-56
Time frame: Baseline
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