Comparison of Longitudinal Blood Pressure and Arterial Stiffness in Preeclamptic Women After Delivery

Seoul National University Hospital73 enrolled

Overview

The investigator measured the arterial stiffness using cardio-ankle vascular index (CAVI) test in patient with preeclampsia and normal pregnant women to evaluate the longitudinal change of CAVI and their predictors.

This study was a case control study and included 37 women with preeclampsia (PE group) and 36 normotensive women (control group) who gave birth to child at Seoul National University Bundang Hospital. Cario-ankle vasuclar index (CAVI) was measured at one day, six months and one year after delivery in both group. The investigator also checked the body weight, blood pressure, lipid profile, serum creatinine, aspartate transaminase (AST) and alanine transaminase (ALT) simultaneously with CAVI. The relationship between the presence of preelampsia and longitudinal changes of CAVI, blood pressure and metabolic indices were evaluated using generalized estimating equation (GEE) method.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Preeclampsia and Eclampsia Stiffness, Aortic Blood Pressure

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 45 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: 1. Case group : Women who were diagnosed preeclampsia based on the criteria of the International Society for the Study of Hypertension in Pregnancy 2. Control group : Normotensive women who gave birth to child at Seoul National University Bundang Hospital. Exclusion Criteria: * Women who were hemodynamically compromised or had bleeding complication after delivery were excluded.

Locations (1)

Seoul National University Bundang Hospital

Seongnam-si, Gyeonggi-do, South Korea

Outcomes

Primary Outcomes

The differences in longitudinal change pattern of CAVI between preeclampsia and normal pregnant women.

The CAVI was analyzed with generalized estimating equation (GEE) method to evaluate the different change pattern of CAVI between two groups.

Time frame: The CAVI was measured at one day, six months and one year after delivery in both groups.