This is a Phase I, FIH, open-label, dose escalation study evaluating Safety and Efficacy of UCART targeting CS1 in patients with Relapsed or Refractory Multiple Myeloma (MM). The purpose of this study is to evaluate the safety and clinical activity of UCARTCS1A and to determine the Maximum Tolerated Dose (MTD).
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
11
Allogenic engineered T-cells expressing anti- CS1 Chimeric Antigen Receptor
UCSF Medical Center- Helen Diller Family Comprehensive Cancer Center
San Francisco, California, United States
Sarah Cannon Research Institute - Colorado Blood Cancer Institute
Denver, Colorado, United States
Winship Cancer Institute Emory University
Atlanta, Georgia, United States
Safety of UCARTCS1A
Incidence, nature and severity of adverse events and serious adverse events (SAEs) throughout the study.
Time frame: 24 months.
Response Assessment
At Day 35, Day 56 (M2), Day 84 (M3), Follow-up \[Q3M up to Month 24; i.e., Month 3, Month 6, Month 9, Month 12, Month 15, Month 18, Month 21 and Month 24
Time frame: 24 months
Duration of Response
Time Frame: From the date of the initial response to the date of disease progression or death from any cause, whichever occurs first, assessed up to Month 24\]
Time frame: 24 months
Progression Free Survival
From the first day of study treatment to the date of disease progression or death from any cause, whichever occurs first, assessed up to Month 24
Time frame: 24 months
Overall Survival
From the first day of study treatment to the date of death from any cause, assessed up to Month 24
Time frame: 24 months
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
Mayo Clinical Cancer Center (MCCC)
Rochester, Minnesota, United States
Hackensack Meridian Health
Hackensack, New Jersey, United States
Sarah Cannon Research Institute - Tennessee Oncology
Nashville, Tennessee, United States
MD Anderson Cancer Center
Houston, Texas, United States
Sarah Cannon Research Institute - Methodist Healthcare
San Antonio, Texas, United States