The objective of this study is to determine if an opioid-free general anesthetic (OFA) technique utilizing lidocaine, ketamine, dexmedetomidine and magnesium reduce postoperative opioid consumption and speed return of bowel function in patients undergoing elective, laparoscopic, colorectal surgery compared to traditional opioid-containing general anesthetic techniques. It is hypothesized that this intraoperative OFA regimen will reduce postoperative opioid consumption, and expedite return of bowel function in this population.
The objective of this trial is to determine whether an opioid-free general anesthetic can help reduce postoperative opioid consumption and speed return of bowel function in patients undergoing elective, laparoscopic, colorectal surgery when compared with traditional opioid-containing techniques.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
TRIPLE
Enrollment
60
975 mg, 300 mg
975 mg, 300 mg
1.5 mg/kg, 0.5 mcg/kg, 0.5 mg/kg
6 mg, 4 mg
Dose titrated to effect, 1.5 mg/kg/hr, 0.15 mg/kg/hr, 0.3 -1 mcg/kg/hr (titrated to effect), 30 mg/kg bolus over 30 minutes
0.5 mg/kg, 0.25-0.5 mcg/kg (titrated to effect)
Dose titrated to effect, As needed (dose at anesthesiologist's discretion)
Royal University Hospital
Saskatoon, Saskatchewan, Canada
RECRUITINGTime to first flatus
Time between the end of surgery and the movement when the patient first passes flatus
Time frame: End of surgery to first flatus (1-4 days)
Time to first defecation
Time between the end of surgery and the moment the patient first passes stool
Time frame: End of surgery to first defecation (1-7 days)
Time to tolerance of oral intake
Time between the end of surgery to when the patient can tolerate any oral solid food intake
Time frame: End of surgery to first oral intake (1-3 days)
Total Post-Anesthetic Care Unit (PACU) opioid consumption
Total amount of opioid (morphine equivalents) required in PACU
Time frame: End of surgery to discharge from PACU (1-2 hours)
Patient Controlled Analgesia (PCA) morphine consumption
Total amount of PCA morphine (mg) required from end of surgery to 48 hours postoperatively
Time frame: End of surgery to 48 hours postoperatively
Time to Post-Anesthetic Care Unit (PACU) discharge readiness
Time to Post-Anesthetic Care Unit (PACU) discharge readiness
Time frame: End of surgery to PACU discharge readiness (1-3 hours)
Visual Analogue Scale (VAS) pain scores
Visual Analogue Scale (VAS) pain scores will be recorded on a scale of 0 to 10, with 0 indicating no pain, and 10 indicating extreme pain, 48 hours following surgery
Time frame: End of surgery to 48 hours postoperatively
Quality of recovery after surgery
Assessed using the Quality of Recovery (QoR) 15 questionnaire, a validated tool for measuring quality of recovery after anesthesia and surgery
Time frame: End of surgery to time of patient discharge from hospital (2-10 days)
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