Strategies to stop AKI-AKD-CKD continuum - Policy is one of the collaborative projects, Strategies to stop AKI-AKD-CKD continuum, Epidemiology, Immunology, Repair, Artificial intelligence, and Policy (EIRAP). It is aimed to study effective interventional strategies that lower the incidence of CKD among patients with AKD. The intensified AKD care to reduce CKD (ISACC trial) is a prospective, open-labeled, randomized controlled trial is designed to evaluate the efficacy of multidisciplinary team care (MDT) model and acute kidney disease (AKD) clinic visits
Acute kidney disease (AKD), defined as the ongoing renal function impairment between 7 days and 90 days following AKI, has been proposed as a window of intervention to prevent the occurrence of CKD. However, the effective therapeutic strategies of AKD care remain to be developed. We intend to conduct a prospective, randomized, open-label, behavioral interventional trial to validate the efficacy of multidisciplinary team (MDT) care model which aims to improve AKD care and to reduce de novo CKD incidence.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
HEALTH_SERVICES_RESEARCH
Masking
NONE
Enrollment
690
Multidisciplinary team (MDT) care: NPDS care model Acute kidney disease (AKD) clinic: layered approach
Proportion of Major adverse kidney event
Proportion of MAKE * Renal progression to CKD * Chronic dialysis (any 1 outpatient dialysis after discharge) * Death
Time frame: 90days
Mortality
Proportion of death
Time frame: 30days, 60days, 90days, 180days, 360 days, 3years
Chronic dialysis
Proportion of chronic dialysis
Time frame: 90days, 180days, 360 days, 3years
Renal progression
Proportion of renal progression to CKD
Time frame: 90days, 180days, 360 days, 3years
Time to MAKE
Time to MAKE
Time frame: 90days, 180days, 1year (360days)
Time to death
Time to death
Time frame: 90days, 180days, 1year (360days)
Time to chronic dialysis
Time to chronic dialysis
Time frame: 90days, 180days, 1year (360days)
Time to renal progression to CKD
Time to renal progression to CKD
Time frame: 90days, 180days, 1year (360days)
Time to first ER visit
Time to first ER visit
Time frame: 90days, 180days, 1year (360days)
Time to first rehospitalization
Time to first rehospitalization
Time frame: 90days, 180days, 1year (360days)
Time to first recurrence of AKI
Time to first recurrence of AKI
Time frame: 90days, 180days, 1year (360days)
Proportion of MACE
CVA, AMI, CHF, or cardiac revascularization procedure
Time frame: 30days, 60days, 90days, 180days, 360 days, 3years
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