Changes in Circulating Sclerostin Levels During Acute Postsurgical Hypoparathyroidism

University of Athens109 enrolled

Overview

To investigate changes in sclerostin levels following acute post-thyroidectomy hypoparathyroidism

Female patients with thyroid disorders, referred to the Department of Head and Neck Surgery, at Metaxa Anti-Cancer Hospital of Piraeus, for total thyroidectomy. Based on the development of biochemical hypocalcemia (cCa \< 8.4 mg/dl), subjects were divided into 2 groups: Group A: without postsurgical hypoparathyroidism that served as controls and group B: subjects, with acute postsurgical hypoparathyroidism. Blood collections were performed in the morning after an overnight fast, in at least 3 different time points; preoperatively, 1st postoperative day and 7th postoperative day for the detrmination of sclerostin levels

Study Type

OBSERVATIONAL

Enrollment

109

Conditions

Hypoparathyroidism Postprocedural

Interventions

calcium carbonate and alphacalcidolDRUG

treatment for hypocalcemia

Eligibility

Sex: FEMALEMin age: 19 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Indication for total thyroidectomy Exclusion Criteria: * parathyroid disorders, chronic kidney disease (eGFR\< 60 ml/min), treatment with antiosteoporosis drugs, rheumatic disease and history of long term (\>1 month) or current corticosteroid use

Locations (1)

Symeon Tournis

Athens, Greece

Outcomes

Primary Outcomes

change in circulating serum sclerostin levels (pmol/L) during the observation period

change in circulating serum sclerostin levels (pmol/L)during the observation period

Time frame: 7 days

Secondary Outcomes

the between groups difference in % changes of circulating sclerostin

Time frame: 7 days

Data from ClinicalTrials.gov

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