Autonomic Activity During Nap Under Hypoxia

Charite University, Berlin, Germany16 enrolled

Overview

Sleeping under hypoxic conditions can impair cognition and autonomic nervous activity. A short daytime nap can modify these changes. Here we propose a randomized, cross-over study to evaluate the heart rate variability during a 90 min nap in a normobaric hypoxic chamber. In addition, we will investigate sleep architecture, vigilance, attention and memory.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

SINGLE

Enrollment

Conditions

Hypoxia Sleep Healthy

Interventions

NormoxiaOTHER

Nap in hypoxia chamber at 20.9% oxygen (36 m asl)

Hypoxia 1OTHER

Nap in hypoxia chamber at 15.0% oxygen (simulates 2660 m asl)

Hypoxia 2OTHER

Nap in hypoxia chamber at 12.8% oxygen (simulates 4000 m asl)

Eligibility

Sex: ALLMin age: 25 YearsMax age: 45 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Men and women * Age 25-45 years * BMI 20 - 28 kg/m\^2 Exclusion Criteria: * Severe, manifest illnesses in need of treatment * Postoperative phases * Acute and chronic infections * Sleep disorders such as sleep apnea, insomnia or somnolence * Altitude exposure (\> 2500 m asl) within 6 months before enrollment * Regular migraines * Smoking * Athletes * Significant weight change within 1 month before enrollment * Inability to understand significance and scope of the study * Drug or alcohol abuse

Locations (1)

Experimental & Clinical Research Center

Berlin, Germany

Outcomes

Primary Outcomes

Heart rate variability

Mean RR interval measured by polysomnography (ms)

Time frame: During 90 minutes nap under normoxic (20.9%) vs. 12.8% hypoxic condition

Secondary Outcomes

Heart rate variability

Mean RR interval measured by polysomnography (ms)

Time frame: During 90 minutes nap under normoxic (20.9%) vs. 15.0% hypoxic condition

Sleep Efficiency (SE)

Measured by continuous polysomnography (min)