Nano-hydroxyapatite and Ozone - Effect on Approximal Initial Caries

Pomeranian Medical University Szczecin92 enrolled

Overview

Objectives: to assess the efficiency of three methods of enamel remineralization on initial approximal caries: 1. a nano-hydroxyapatite gel, 2. gaseous ozone therapy 3. combination of a nano-hydroxyapatite gel and ozone. Materials and Methods: Patients (n=92, age 20-30y) with initial approximal enamel lesions on premolar and molar teeth (n=546) randomly allocated to three groups subjected to a 6-months treatment: Group I: domestic nano-hydroxyapatite remineralizing gel, group II: in-office ozone therapy, group III: both remineralizing gel and ozone therapy. Caries lesions assessed on bitewing radiographs at baseline, after 1 year and after 2 years.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Caries,Dental

Interventions

Eligibility

Sex: ALLMin age: 20 YearsMax age: 30 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: -initial approximal enamel lesions on premolar and molar teeth Exclusion Criteria: * distal surface of the last tooth in arch, overlapping teeth * fillings on approximal surfaces of teeth of interest * ongoing orthodontic therapy with braces or other appliances

Outcomes

Primary Outcomes

Remineralizing effect

Caries lesions were assessed on bitewing radiographs

Time frame: baseline

Secondary Outcomes

Remineralizing effect - follow-up

Caries lesions were assessed on bitewing radiographs

Time frame: after 1 year and after 2 years