PROTECTED TAVR: Stroke PROTECTion With SEntinel During Transcatheter Aortic Valve Replacement

Inclusion Criteria: * Subject has documented aortic valve stenosis and is treated with an approved TAVR device via transfemoral access * Subject has the recommended artery diameter at the site of filter placement per the Sentinel® Cerebral Protection System Instructions For Use: 9-15 mm for the brachiocephalic artery and 6.5-10 mm in the left common carotid artery. * Subject (or legal representative) provides written informed consent. Exclusion Criteria: * Subject has arterial stenosis \>70% in either the left common carotid artery or the brachiocephalic artery. * Subject's brachiocephalic or left carotid artery reveals significant stenosis, ectasia, dissection, or aneurysm at the aortic ostium or within 3 cm of the aortic ostium. * Subject has compromised blood flow to the right upper extremity. * Subject has access vessels with excessive tortuosity. * Subject has uncorrected bleeding disorders. * Subject is contraindicated for anticoagulant and antiplatelet therapy.