Children due for elective eye surgery in propofol based anesthesia will be kept at steady state propofol infusion for maintenance, ventilation via endotracheal tube. Exhaled propofol will be measured continously by Edmon (R) (BBraun) monitor and compared with arterial plasma samples of propofol, drawn 3-5 times during the procedure.
The primary objective of the study is to determine the correlation between simultaneous concentrations of propofol in plasma and expiratory air in children during general anesthesia. Key secondary objectives include correlating plasma and exhaled measurements of propofol with electroencephalogram (BIS) values and computer estimated propofol concentrations in plasma and brain (TCI: target control infusion) Primary endpoint: Exhaled air and plasma concentration ratios of propofol during general anesthesia in children.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
32
New device for exhaled propofol concentration measurements
Oslo University Hospital
Oslo, Norway
Propofol plasma concentration versus simultaneous exhaled concentration
repeated blood samples of propofol concentration
Time frame: 5 hours
Realtionship between Paedfusor-estimated propofol concentration and measured concentration in plasma samples
Time frame: During general anaesthesia
Propofol exhaled correlation versus Bispectral Index value (BIS)
repeated blood samples of propofol concentration
Time frame: 5 hours
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