Xingnaojing for Mild-to-severe Acute Ischemic Stroke

Inclusion Criteria: * Diagnosis of Acute ischemic stroke； * Symptom onset within 24 hours； * Age ≥ 18 and ≤ 80 years； * NIHSS score ≥ 4 and ≤ 25； * Patient or legally authorized representative has signed informed consent. Exclusion Criteria: * Planned or already receiving intravenous thrombolysis or endovascular treatment; * Suspected secondary stroke caused by tumor, brain trauma, or hematological diseases; * Already dependent in activities of daily living before the present acute stroke (defined as modified Rankin Scale score ≥ 2) ; * Other conditions that cause cardiogenic embolism (e.g., atrial fibrillation, rheumatic heart disease, valvular heart disease); * Other conditions that lead to motor dysfunction (e.g., severe osteoarthrosis, rheumatoid arthritis); * Significant renal or hepatic insufficiency (defined as a serum creatinine concentration, alanine aminotransferase (ALT), or aspartate aminotransferase (AST) value that is twice the upper limit of normal); * Life expectancy of 3 months or less due to other life-threatening illness (e.g.,advanced cancer) * Other conditions that render outcomes or follow-up unlikely to be assessed; * Known to be pregnant or breastfeeding; * Currently receiving an investigational drug;