Examining The Effect of Blood Flow Restricted Aerobic Training on Mitochondrial Adaptations in Young Healthy Adults

Brendon Gurd, PhD19 enrolled

Overview

This parallel-arm trial study investigates the effects of restricting arterial blood flow during cycling exercise on citrate synthase. Participants will be randomized to either a blood flow restricted or non-blood flow restricted exercise training group. Both groups will complete seven, 30-minute exercise sessions over a 14-day period.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

DOUBLE

Enrollment

Conditions

Mitochondrial Biogenesis

Interventions

BFR Exercise TrainingOTHER

Participants will complete exercise training on a recumbent bike placed on a 45 degree incline (BFR).

CTL Exercise TrainingOTHER

Participants will complete exercise training on a recumbent bike placed on flat ground (CTL).

Eligibility

Sex: ALLMin age: 18 YearsMax age: 30 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * 3 hours of physical activity per week * No previous cycling training * No concurrent involvement in another training program * Body mass index \< 30 kg/m2 Exclusion Criteria: * Presence of cardiovascular disease * Presence of metabolic disease * Taking regular oral medication * Current smoker

Locations (1)

Queen's University

Kingston, Ontario, Canada

Outcomes

Primary Outcomes

Citrate Synthase

Fold change in citrate synthase maximal activity

Time frame: 3 days prior to start of exercise training and 3 days after completing exercise training

Secondary Outcomes

Transcription factor A, mitochondrial (TFAM)

Fold change in TFAM protein

Time frame: 3 days before training to 3 days after training

Nuclear respiratory factor, 1 (NRF1)

Fold change in NRF-1 protein

Time frame: 3 days before training to 3 days after training

Maximal oxygen consumption (VO2peak)

Change in VO2peak (POST-PRE)

Time frame: 3 days before training to 3 days after training

Heart rate (HR)

Average HR

Time frame: Every 5 minutes during each of the 7, 30-minute exercise sessions

Revolutions per minute (RPM)

Average RPM

Time frame: Every 5 minutes during each of the 7, 30-minute exercise sessions

Blood [lactate]

Average blood lactate concentration

Time frame: During all exercise sessions at 10 and 30 minutes

Rating of perceived exertion (RPE)

Average RPE

Time frame: Every 5 minutes during each of the 7, 30-minute exercise sessions

Data from ClinicalTrials.gov

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