Endothelin Concentrations in a Population With Cardiovascular Disease and Periodonitis

N/ACompletedNCT04152005

University of Messina165 enrolled

Overview

Recently, a key role played in the ethiology of periodontitis has been highlighted by a Endothelin (ET-1). ET1 possess the ability to express surface antigens of endothelial and hematopoietic stem cells and to assist in maintaining vascular integrity and the repair mechanism of the endothelium. ET originate from bone marrow

The aim of the present study was to investigate the association between ET-1 in patients with periodontitis. Furthermore, the objective was to determine if the periodontal status influenced ET-1 levels.

Study Type

OBSERVATIONAL

Enrollment

165

Conditions

Serum; Disease

Interventions

ObservationOTHER

Evaluation of ET-1 level and correlation of ET-1 levels with periodontal and cardiovascular disease

Eligibility

Sex: ALLMin age: 21 YearsMax age: 71 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Presence of at least 16 teeth * CP with a minimum of 40% of sites with a clinical attachment level (CAL) ≥2mm and probing depth (PD) ≥4mm; * Presence of at least ≥2 mm of crestal alveolar bone loss verified on digital periapical radiographs * Presence of ≥40% sites with bleeding on probing (BOP) Exclusion Criteria: * Intake of contraceptives * Intake of immunosuppressive or anti-inflammatory drugs throughout the last three months prior to the study * Status of pregnancy or lactation * Previous history of excessive drinking * Allergy to local anaesthetic * Intake of drugs that may potentially determine gingival hyperplasia such as Hydantoin, Nifedipine, Cyclosporin A or similar drugs.

Locations (1)

University of Messina

Messina, Italy

Outcomes

Primary Outcomes

Evaluation of ET-1 levels

Correlation of ET-1 levels with periodontal and cardiovascular disease

Time frame: 1 year

Data from ClinicalTrials.gov

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