Treatment of chronic migraineurs who have failed more than 3 preventive drugs with Erenumab alone, to reduce frequency of monthly migraine days or as an add on therapy
The investigators treated chronic migraineurs that have failed more than 3 preventive drugs with Erenumab alone or as an add on therapy to: Reduce the frequency of monthly migraine days, to evaluate If the add on of Erenumab to another preventive therapy is superior to Erenumab alone, and assess all adverse events related to the use of Erenumab. Migraineurs with 15-30 migraie days per month at baseline were clustered in 3 categories. Failure of Erenumab was defined as no improvement in the frequency of monthly migraine days. Group I: no preventive therapy, prior to the start of Erenumab. (No botox cohort). Group II: on Botulinum Toxin A (Botox), prior to the add on therapy with Erenumab. (Botox cohort).Group III: on an oral preventive drug, prior to the add on therapy with Erenumab. (No Botox cohort)
Study Type
OBSERVATIONAL
Enrollment
158
Assess synergy of add on medication to Erenumab
Guy Pierre Boudreau
Montreal, Quebec, Canada
Change in monthly migraine days
Change in frequency of monthly migraine days
Time frame: 5 months
Change in frequency of monthly migraine days adding Erenumab to another preventive treatment,
Change in the frequency of monthly migraine days with Botox plus Erenumab,
Time frame: 5 months
Change in the frequency of monthly migraine days adding Erenumab to another preventive treatment
Change in the freqyency of monthly migraine days with an oral preventive plu erenumab
Time frame: 5 months
change in frequency of monthly migraine days with Erenumab alone
change in frequency of monthly migraine days without adding another preventive to Erenumab
Time frame: 5 months
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