Study to Assess Intracerebroventricular (ICV) Delivery of CT-010 in Subjects With Focal Seizures, With Temporal Lobe Onset With or Without Secondary Generalization

Inclusion/Exclusion Criteria: \- For a subject to be eligible for this study, he or she must meet ALL of the following criteria: 1. Subject is male or female between the ages of 18 to 70 years old. 2. Subject is considered an appropriate surgical candidate by the implanting Neurosurgeon. 3. Subject has had confirmed refractory epilepsy for a minimum of 2 years, with unilateral or bilateral temporal lobe involvement with no more than 2 known extratemporal foci. 4. In the opinion of the Investigator, subject has disabling seizures. 5. Subject has had at least one seizure recorded by EEG or video EEG or invasive monitoring within the past 3 years consistent with focal temporal lobe seizures (a normal interictal EEG is consistent with focal seizures) 6. Subject has not achieved effective results previously from at least 3 AEDs in single or combination. An AED may be counted as failed medication if subject has been on it for at least 3-months and is still refractory. 7. Subject failed to obtain an adequate intake of oral valproate of at least 1,000 mgs a day and/or to achieve serum level of at least 60 µg/mL or in the opinion of the Investigator is not a candidate for oral valproate (including subject preference) 8. Per medical history, for the 3 months before informed consent an average of six or more disabling focal seizures of temporal lobe onset, with or without secondary generalization, per month. 9. Subject has seizures that are distinct, stereotypical events that can be reliably counted, in the opinion of the Investigator, by the subject or caregiver. 10. Subject understands study procedures and has voluntarily provided signed, informed consent in accordance with institutional and local regulatory requirements. 11. Subject agrees to maintain the diary for the duration of the study alone or with the assistance of a competent individual. Subjects must NOT meet any of the following Exclusion criteria to be eligible for enrollment: 1. Subject has any neurologic or medical disease that is likely to progress over the course of the study and/or would interfere with the study. 2. Subject has any coagulopathy, ventricular anatomic distortion, or previous brain resection. 3. Subject has history, within 12 months prior to consent, of repetitive seizures that cannot be counted with confidence by the subject or competent adult/caregiver. 4. Subject has history of psychogenic nonepileptic seizures or seizures secondary to illicit drug or alcohol use, neoplasia, active central nervous system infection, demyelinating disease, degenerative neurological disease, progressive CNS disease or metabolic illness. 5. Subject has had status epilepticus refractory to benzodiazepines and a second agent within one year prior to consent 6. Subject is currently taking neuroleptic medication for behavior control. 7. Subject has a clear brain anatomic structural related lesion which distorts the normal anatomy or interferes with CSF fluid flow. 8. Subject has required (in addition to low dose stable use of benzodiazepines as part of antiepileptic regimen), in the 3 months prior to consent, benzodiazepine use more than 5 times per month for rescue seizure control. One use is defined as taking up to 3 doses in a 24-hour period. 9. Subject is currently implanted with an activated DBS, or RNS device used for treatment of a neurologic or psychiatric condition. 10. Subject currently has VNS and the VNS stimulation parameters are not stable. Stable shall be defined such that the stimulation parameters have not been changed in the last 3 months or the patient/designee is able to report "magnet swipe" during the same time period. The Investigator believes that the continued stable parameters can be maintained through the Primary Evaluation Period. 11. Subject has had more than 10 seizures in one day or more than 200 seizures in one month within last year. 12. Subject has known allergy to citrate, citric acid, valproic acid, divalproex sodium, any components of CT-010, or Depacon®. 13. Subject has unstable depression being treated with more than 1 antidepressant medication or has current evidence of or history within the past 2 years of DSM-IV criteria for any major psychiatric disorder including psychosis, major depression, bipolar disorder, and has had a suicide attempt within the previous five years. Also excluded are subjects with a history of prolonged postictal psychosis or psychosis or depression secondary to a discontinued AED. 14. In the opinion of the Investigator, the subject has a clinically significant or unstable medical condition (e.g., uncontrolled diabetes or CHF) or a progressive CNS disease that would limit the subject's entry into the study