Earlier Mobilization Post Acute Thrombolysis

Inclusion Criteria: * Age 18 years or older * Received intravenous tPA for a clinical diagnosis of acute ischemic stroke * Patient and/or Legally Authorized Representative provide consent Exclusion Criteria: * Venous thromboembolism present at symptom onset * Pneumonia present at symptom onset * STEMI at symptom onset * Positive troponins at symptom onset according to local values * Bone fracture at symptom onset * Treatment includes or anticipated to include thrombectomy * Intubation anticipated or occurred * Symptomatic intracranial hemorrhage (defined as increase in NIHSS by 4 points or more accompanied by PH2 hemorrhage on imaging) at the time of screening. * Pre-screening systolic blood pressure \< 110 mmHg * Resting pulse oximetry \< 92% (with or without supplemental oxygen) * Neurological worsening (defined as NIHSS increase of 4 points compared to initial score) prior to screening. * Baseline modified Rankin Scale score \> 2 * Known pregnancy * Patient not anticipated to survive 3 months * Patient not anticipated to follow-up at 3 months