NCT04154540 - Posturography-Neuropathy | Crick | Crick

Posturography-Neuropathy

N/ACompletedNCT04154540

University Hospital, Lille67 enrolled

Overview

If the classification between hereditary and acquired neuropathy is often easy, there is no completely specific marker allowing the distinction between the two etiologies. Clinical experience suggests that hereditary neuropathies have less impact on balance and gait than the acquired neuropathies at equivalent level of impairment, but this has never been clearly demonstrated.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

OTHER

Masking

NONE

Enrollment

67

Conditions

Neuropathy Demyelinating

Interventions

Motion analysisOTHER

Gait and posture recording

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * CMT1A for molecular-proven Group 1 (PMP22 duplication) * IPDC likely or defined for Group 2 * Able to walk 10 m unassisted Exclusion Criteria: * Neurological history other than neuropathy: epilepsy, stroke, dementia * Pregnant women * Person under guardianship or trusteeship * Musculoskeletal conditions other than neuropathy impairing walking abilities * Major comorbidity considered a contraindication by the investigator (cancer, unstable angor, etc.)

Locations (1)

Hôpital Roger Salengro, CHU

Lille, France

Outcomes

Primary Outcomes

Posturography (Romberg's quotient)

Time frame: Time 0 ; single session

Secondary Outcomes

The Timed Up and Go test (TUG)

It uses the time that a person takes to rise from a chair, walk three meters, turn around, walk back to the chair, and sit down. the scores of ten seconds or less indicate normal mobility, 11-20 seconds are within normal limits for frail elderly and disabled patients, and greater than 20 seconds means the person needs assistance outside and indicates further examination and intervention. A score of 30 seconds or more suggests that the person may be prone to falls

Time frame: Time 0 ; single session

stride length (in millimeters) parameters

Kinematic and Kinetic parameters of the gait initiation and the stabilised gait using the optoelectronic system (VICON®)

Time frame: Time 0 ; single session

stride time (in seconde) parameters

Kinematic and Kinetic parameters of the gait initiation and the stabilised gait using the optoelectronic system (VICON®)

Time frame: Time 0 ; single session

velocity (meter/seconde) parameters

Kinematic and Kinetic parameters of the gait initiation and the stabilised gait using the optoelectronic system (VICON®)

Time frame: Time 0 ; single session

cadence (step/min) parameters

Kinematic and Kinetic parameters of the gait initiation and the stabilised gait using the optoelectronic system (VICON®)

Time frame: Time 0 ; single session

Data from ClinicalTrials.gov

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