Atrial fibrillation and inflammation are strongly correlated. The aim of this study is to evaluate whether inflammation markers (alpha Defensin) predict maintenance of sinus rhythm following cardioversion. A secondary aim is to evaluate the role of Colchicine, an anti-inflammatory medication, in reducing the recurrence rate of atrial fibrillation.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
300
Administration of Colchicine at a dose of 0.5mg 2x a day for six months.
Electrical or pharmacologic restoration of sinus rhythm
Hillel Yaffe Medical Center
Hadera, Israel
Recurrence of atrial fibrillation
Atrial fibrillation recurrence rates over the next 12 months will be determined based on medical records and ECG documentation between treatment group (Colchicine) and control group.
Time frame: 12 months
Alpha Defensin levels in patients with recurrence of atrial fibrillation
Alpha Defensin levels will be measured in patients with recurrence of atrial fibrillation and compared to levels in patients without recurrence.
Time frame: 12 months
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